Caution in Interpreting Results of CT-Cancer Association Study

To the Editor The recent article by Smith-Bindman et al projects that computed tomography (CT) imaging in 2023 may account for up to 5% of all future cancer diagnoses in the US based on the linear no-threshold model of radiation risk. While technically rigorous, the study relies on an extrapolative framework that remains deeply contested in radiation biology and toxicology. The linear no-threshold model presumes that any dose of ionizing radiation, however small, proportionally increases cancer risk, a claim that lacks empirical validation at diagnostic dose levels and ignores evidence of dose thresholds and biological repair mechanisms.

from JAMA Internal Medicine Online First https://ift.tt/1AMwhEt